| USP-NF2024 | |
| 98.0%~102.0% | |
| 1) Comparing with the spectrum obtained with CRS 2) The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay |
|
| 1.0% max | |
| 0.15% max | |
| (1) Impurity A: 0.05% max (2) Individual unspecified impurity: 0.05% max (3) Total impurities: 0.1% max |
1. Pharmaceutical Use
Historically used as a non-opioid analgesic and antipyretic to reduce pain and fever.
Its analgesic and antipyretic properties make it a prototype for the development of other non-steroidal anti-inflammatory drugs (NSAIDs).
Used in clinical settings as a pharmacokinetic marker to study liver enzyme activity and drug metabolism, particularly cytochrome P450 enzymes.
2. Biochemical and Pharmacological Research
Employed as a probe drug for studying hepatic enzyme function because of its predictable metabolism.
Used in in vitro and in vivo metabolism studies to evaluate the activity of drug-metabolizing enzymes.
3. Analytical Chemistry
Acts as a reference compound in high-performance liquid chromatography (HPLC) and other analytical methods.
Used in testing and calibration due to its well-characterized properties.
1. Well-Characterized Metabolic Profile
The metabolism of antipyrine is well understood, making it a reliable compound for assessing liver enzyme activity and drug interactions.
2. Broad Research Utility
Its use as a pharmacokinetic marker enables researchers to study drug metabolism variability in different populations or under different conditions.
3. Stable and Easy to Handle
Antipyrine is chemically stable and easy to formulate in laboratory studies.
Antipyrine (CAS 60-80-0) is a classic pyrazolone derivative with historical use as an analgesic and antipyretic agent. Today, its primary value lies in pharmacological and biochemical research as a probe for liver enzyme activity and drug metabolism. Its well-established metabolic profile and chemical stability make it an indispensable tool in pharmacokinetic and toxicological studies.
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